Left click unresponsive on Apple MacBook Pro

My left click on both my trackpad, and my wireless Anker mouse become unresponsive after about 5-10 mins of heavy use, usually when I am in After Effects. Troubleshooting leaves BetterTouch to be the most likely culprit, but I can't be certain if it's conflict with the OS, browser, or an Adobe application. If I boot into safe mode, the error can't be replicated. Once it's stuck, I can only use my keyboard to activate a left click.