I am looping back on this topic.
I seem to be having a similar issues and am running MacOS 15.3.
When using Option + (a letter), my shortcut action will often times not be triggered but a special character will be typed instead.
I use these type of Option + (a letter) trigger in Chrome, in most cases.
My company used to have their own Mac app which they moved a few days ago to a web-based app on Chrome.
Now a lot of my shortcuts are unusable unfortunately.
Is there a workout apart from remapping all my shortcuts (and muscle memory) ?
Thanks in advance !